Webinar: Insights to Heart Development and Disease using Single-Cell Analysis and In Vitro Modeling of Pluripotent Stem Cells

Date: June 24, 2021 Time: 8:00 am (PDT), 11:00 am (EDT)

Cardiovascular disease is a leading health problem, affecting almost 30% of individuals in the developed world, and comprises a wide range of disorders from acute heart failure to congenital heart abnormalities. While complex genetic mechanisms are thought to underlie many types of heart disorders, the lack of reliable model systems that recapitulate heart development and disease is hampering the mechanistic understanding and dissection of disease phenotypes. With the capability to differentiate into any type of body cell, pluripotent stem cells (PSCs) have emerged as a powerful tool to study human development and disease biology.

Join this webinar to understand how robust PSC-based platforms and tools are being used to study cardiovascular development, maturation, and disease phenotypes. These technologies include microfluidics-based sorting of cardiomyocytes, single-cell transcriptomics and in vitro functional assays to model cardiac development using cardiac progenitor cells. The development of new PSC-based targeted therapies aimed at treating cardiac diseases will also be discussed.

Who should attend
This webinar will provide insights to researchers who want to learn about how PSCs can be used to study cardiac development and disease.

Key learning objectives

• Outline how PSCs differentiate into cells of different lineages and their use in modeling development and disease
• Review single-cell analysis techniques utilized for isolation and analysis of cardiac progenitor cells used for modeling heart development and disease
• Examine in-vivo maturation systems for iPSC-based modeling of cardiomyopathy

Speakers
Dr. Peter Andersen – Assistant Professor and Group Leader at Johns Hopkins University School of Medicine and Co-founder of Vita Therapeutics