Date: Wednesday, January 20, 2021 at 8:00 PST | 11:00 EST | 16:00 GMT | 17:00 CET
Presented by SelectScience
Cell sorting is an indispensable tool widely used for purifying cell populations implicated in immune response, immunotherapy, vaccine development and infectious disease. This webinar focuses on work from eminent scientists in area of infectious disease research who are using the Sony MA900 Cell Sorter to purify rare immune cell subsets implicated in the pathophysiology of the disease and profiling them using other key downstream technologies to understand the intricacies of the immune system at a single cell resolution.
The pathogenesis of severe COVID-19 reflects an inefficient immune reaction to SARS-CoV-2. The dynamics of adaptive immune response in COVID-19 patients requiring intensive care can be studied by single cell analysis of the plasmablasts egressed into the blood. These studies show that before seroconversion in response to SARS-CoV-2 spike protein, peripheral plasmablasts display a type 1 interferon-induced gene expression signature. Following seroconversion, plasmablasts lose this signature, expressing instead gene signatures induced by IL-21 and TGF-β.
Join this webinar from Single-Cell Laboratory for Advanced Cellular Therapies lab at German Rheumatism Research Centre, Berlin (DRFZ) to learn about the mechanism of the adaptive immune response generated in severe cases of COVID-19 and the role played by TGF-β in the chronic immune reaction. Insights from transcriptome and immune repertoire profiling of T and B cells isolated from COVID-19 patients using the Sony MA900 cell sorter will be discussed.
Who should attend
Researchers who are interested in the mechanism of the adaptive immune response generated in severe cases of COVID-19 and the role played by TGF-β in the chronic immune reaction will benefit from this webinar.
Dr. Marta Ferreira-Gomes
German Rheumatism Research Centre (DRFZ), Berlin
Date: Tuesday, Nov. 30, 08:00 PST / 11:00 EST / 16:00 GMT / 17:00 CET